SCIENTIFIC POSTER
Parkinson disease-related phenotype characterization of A53T alpha-synuclein iPSC-derived dopaminergic cultures
Parkinson disease (PD) is a progressive neurological disease caused by selective loss of dopaminergic neurons in the substantia nigra. Although the majority of PD cases are sporadic, familial PD mutations provide a valuable tool for understanding and modelling basic pathophysiological mechanisms. We used MyCell® DopaNeurons carrying the A53T mutation in the SNCA gene (A53T DaNs) and healthy isogenic control iCell® DopaNeurons (WT DaNs) to investigate disease-relevant phenotypes including:
- alpha synuclein (αSyn) accumulation
- mitochondrial dysfunction
- calcium dysregulation
Recently presented at the Society for Neuroscience 2019 conference in Chicago by our expert, Teresa Ferraro, download your copy of this scientific poster now and discover more.